Richard Brooks 2013 When a small group of people from differing professional backgrounds and disciplines met in 1987 with the common aim of developing a health-related quality of life instrument that would suit their requirements it is doubtful if any of the participants expected that the resulting instrument would have the global reach it has today. This book shows […]

Alberto J. L. Macario Everly Conway de Macario Francesco Cappello 2013 Diseases with Defective Molecular Chaperones This book is about a number of pathological conditions, the chaperonopathies, which probably existed since remote times and have been studied for years but were grouped together in a coherent nosological category only recently. The book is intended to be an introduction […]

John Geigert 2013 Preparing the 2nd edition of my book was a humbling experience for me. My primary purpose for updating the 1st edition was to continue to provide relevant insight and practical suggestions for a risk-managed, common sense, scientific, practical business approach to managing the Chemistry, Manufacturing and Controls (CMC) regulatory compliance requirements and expectations for biopharmaceuticals as human […]

Mauricio G. Mateu Editor 2013 An Integrated Textbook Structural Virology is today an all-important discipline that permeates most other virological disciplines. The application of physical and physicochemical techniques has led to the determination of the high-resolution molecular structures of many viruses.

Quincy Teng 2013 Practical NMR Applications The second edition of “Structural Biology: Practical NMR Applications” retains the focus of the previous edition, which is to provide readers with a systematic understanding of fundamental principles and practical aspects of NMR spectroscopy. At the beginning of each section, questions and objectives highlight key points to be learned, and homework problems are […]

David Mittelman Editor 2013 In 1942, Julian Huxley referred to the cross-disciplinary, unified evolutionary theory as the modern evolutionary synthesis . In the early part of the twentieth century, Fisher, Haldane, and Wright—and later Mayr, Dobzhansky, and others—produced a revised model of Darwinian evolution that rationalizes Mendelian genetics in the context of natural selection.

Parag Kolhe • Mrinal Shah • Nitin Rathore Editors 2013 Formulation, Process, Quality and Regulatory Considerations Sterile products represent a significant fraction of parenteral products and encompass a variety of challenging dosage forms. Development of sterile products poses multifaceted challenges which can be broadly categorized into three areas: formulation dosage form development, processing and manufacturing and assurance of […]

Scott D. Cramer Editor 2013 Prostate cancer is common and kills people every day. Recently, understanding of the biology of adult tissue stem cells and their cognate cancers has identified striking similarities in normal stem cells and tumor-initiating cells, or the so-called cancer stem cells. The defining properties of a stem cell are self-renewal and multilineage differentiation. Many cancers […]

Willy Østreng, Karl Magnus Eger, Brit Fløistad, Arnfinn Jørgensen-Dahl, Lars Lothe, Morten Mejlænder-Larsen and Tor Wergeland 2013 A Comparison of the Northeast, Northwest and Trans Polar Passages