Transient Receptor Potential Channels

Transient Receptor Potential Channels-1

Md. Shahidul Islam Editor 2011 During a conference titled “TRP channels, from sensory signaling to human disease”, held at the Karolinska Institute, Stockholm, Sweden, on 26th and 27th September, 2009, I was contacted by Springer to publish the proceedings of the conference. After some discussion with some of the speakers, I understood that that was not going to happen. […]

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The Science and Business of Drug Discovery

The Science and Business of Drug Discovery-1

Edward D. Zanders 2011 Demystifying the Jargon Jargon, according to the Concise Oxford Dictionary, can either mean unintelligible words, or gibberish, barbarous or debased language, or else a mode of speech only familiar to a group or profession. Anyone trying to approach the drug discovery industry from the outside might have some sympathy with all of these definitions, particularly […]

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The Minimal Cell

The Minimal Cell-1

Pier Luigi Luisi ● Pasquale Stano Editors 2011 The Biophysics of Cell Compartment and the Origin of Cell Functionality The main reason behind this book was the necessity to give a proper account to the considerable interest that arose in the last ten years on the notion of minimal cell. This is broadly defined as the cell […]

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Small-Molecule Inhibitors of Protein-Protein Interactions

Small-Molecule Inhibitors of Protein-Protein Interactions-1

Lyubomir Vassilev, David Fry Editors 2011 Cell integrity and functions depend on a myriad of protein–protein interactions. Many of these interactions are involved in disease etiology and represent desirable targets for pharmacological intervention. However, the notion of modulating protein–protein binding with small molecules has historically raised serious concerns.

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Mouse as a Model Organism

Mouse as a Model Organism-1

Cord Brakebusch · Taina Pihlajaniemi Editors 2011 From Animals to Cells The importance of mice as model organism has continuously increased throughout the last decades due to the widespread use of genetically modified mice. These mice significantly increased our understanding of the function of specific genes in a living mammalian organism during development and in disease.

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MicroRNAs in Cancer Translational Research

MicroRNAs in Cancer Translational Research-1

William C.S. Cho Editor 2011 MicroRNAs (miRNAs) have a revolutionary impact on cancer research over recent years. These small non-coding RNAs emerge as important players in tumorigenesis, leading to a paradigm shift in oncology. The rapid discovery of many miRNA targets and their associated pathways has contributed to the development of miRNAbased therapeutics for cancer.

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