Edited by BRIAN I. CARR 2005 DIAGNOSIS AND TREATMENT Hepatocellular carcinoma (HCC) used to be regarded as a rare disease. The increasing numbers of chronic hepatitis C virus carriers in the United States and subsequent increased incidence of HCC seen in most large medical centers means that it is no longer an uncommon disease for most gastroenterologists or oncologists […]

U. Veronesi and K. Redmond 2005 The Cancer Futures Collection 2001–2004  

Edited by WAFIK S. EL-DEIRY 2005 The study of cell death, or apoptosis, has turned into a very large field. Both the extrinsic and intrinsic cell-death pathways appear to have fundamental importance to tumor progression and cancer therapy. It has become clear that the extrinsic pathway provides a number of mechanisms for host immune surveillance of tumors and […]

Edited by GARY K. SCHWARTZ 2005 MODULATORS AND POTENTIATORS The concept of combining chemotherapeutic agents to increase cytotoxic efficacy has evolved greatly over the past several years. In the past, the rationale for combination chemotherapy centered on attacking different biochemical targets, overcoming drug resistance in heterogenous tumors, and increasing the dose-density of combination chemotherapy to take advantage of tumor […]

Edited by VAL R. ADAMS THOMAS G. BURKE 2005 Clinical interest in the camptothecins continues to expand despite the fact that this class of agents has been studied for almost 50 years and two early generation members of the family have gained FDA approval. To date, the intensive research efforts carried have clearly validated the utility of this […]

Edited by GURMIT SINGH SHAFAAT A. RABBANI 2005 Bone Metastasis: Experimental and Clinical Therapeutics is intended as an introduction to the molecular underpinnings of bone metastasis. Contributions from internationally recognized authorities on the fundamental concepts, current treatment approaches, and future therapeutic strategies provide a synopsis of bone metastasis.

Edited by LODOVICO BALDUCCI MARTINE EXTERMANN 2005 The population of Western countries is aging, and cancer in older aged persons is becoming increasingly common. The management of these neoplasms is a novel problem.